Metrogyl Gel Mechanism of Action

Pharmacology: Pharmacodynamics: Metronidazole is an effective, broad-spectrum antiprotozoal and antibacterial drug from the group of nitroimidazole. It is effective for the clinical treatment of patients with pyro-inflammatory diseases.
Pharmacokinetics: Bioavailability studies on the topical administration of 1 gram of Metronidazole of gel to face of 10 rosacea patients showed a maximum serum concentration of 66 nanograms per mililiter in one patient. This concentration is approximately 100 times less than concentration afforded by a single 250mg oral tablet. The serum metronidazole concentrations were below the detectable limits of the assay at the majority of time points in all patients. Three of the patients detectable serum concentration of metronidazole at any time point. The mean dose of gel applied during clinical studies was 600mg which represents 4.5mg of metronidazole per application. Therefore, under normal usage levels, the formulation affords minimal serum concentration of metronidazole.